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Answers to Week 6 FINALS Questions

 

This photograph depicts a patient with acral lentiginous melanoma. Which one of the following terms is used to designate the hyperpigmentation of the proximal nail fold?

 

    A  Auspitz sign
    B 
Nikolsky’s sign
    C  
Hutchinson’s sign
    D  Papular urticaria
    E  Lichenification

Acral lentiginous melanoma is an unusual form of malignant melanoma that occurs on acral sites (palms, soles, nailbeds). This form of melanoma is the most common form in black patients. These tumors often have a poor prognosis, because by the time of diagnosis, they have often invaded deeply into the dermis. Hutchinson's sign (pigmentation of the proximal nail fold) is a nonspecific finding in some cases of acral lentiginous melanoma.


 

2  All of the following antibiotic groups are generally known to be bactericidal except:

    A   aminoglycoside
   
B  vancomycin
   
C  fluoroquinolone
    D  
chloramphenicol
 

Chloramphenicol is a bacteriostatic inhibitor of protein synthesis.  Penicillins, cephalosporins, vancomycin, aminoglycosides, quinolones, and polymyxins are generally considered bactericidal (ie, they kill bacteria). Erythromycin, tetracyclines, chloramphenicol, clindamycin, lincomycin, clarithromycin, azithromycin, and sulfonamides are generally bacteriostatic (ie, they slow bacterial growth).


 

3   All of the following may be associated with bacteria endocarditis except:

    A  Osler's nodes
    B  Roth's spots
    C  calcinosis cutis
    D  petechiae
   

calcinosis cutis (it's calcification in the skin as part of CREST syndrome).  Diffuse soft tissue calcification (calcinosis cutis) is a rare complication of systemic lupus erythematosus, and resembles the calcification that is more commonly noted in systemic sclerosis and dermatomyositis. It tends to develop in patients diagnosed with SLE at a young age.  For an intriguing case study on this topic see:  http://www.hopkins-arthritis.som.jhmi.edu/radrds/radiology_7/7_radrds.html

 

4  Howell-Jolly bodies may be present in patients with all of the following except:

    A  aplastic anemia
    B  megaloblastic anemia
    C  hemolytic anemia
    D  post splenectomy
   

Howell-Jolly bodies are spherical blue-black inclusions of red blood cells seen on Wright-stained smears. They are nuclear fragments of condensed DNA, 1 to 2 µm in diameter, normally removed by the spleen. They are seen in severe hemolytic anemias, in patients with dysfunctional spleens or after splenectomy.

5  All of the following sensory information is carried via the posterior column except:

    A  vibratory sense
    B  conscious proprioception
    C  temperature
    D  light touch

The lateral spinothalamic tract carries sensation of pain, temperature, and crude tactile sensation.


 

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