RUMBLE 2006
Answers to Week 2 Questions

1. In tracing back the cellular lineage of osteocytes, which of the
following is NOT typically found?:

a. osteoblasts

b. hematopoietic stem cells

c. stromal cells

d. pre-osteoblasts

Answer B. Osteocytes are derived from osteoblasts which are ultimately derived from mesenchymal stem cells. Click this link for some great bone biology information: http://depts.washington.edu/bonebio/ASBMRed/cells.html#diff

 

2. The process of indirect osseous repair is typically a progression from:

a. Cartilage callus to hematoma to ossification

b. Hematoma to cartilage callus to ossification

c. Epithelialization to hematoma to ossification

d. Cutting cone to woven bone to ossification

Answer B. Indirect osseous repair (secondary bone healing) is dependent on the orderly progression from hematoma to callus to eventual ossification. Ref: McGlamry’s Comprehensive Textbook of Foot and Ankle Surgery, Third Edition, Volume 1, Chapter 4, page 67.

 

 3.  True or False: Direct osseous repair leads to a FASTER rate of healing than indirect osseous repair.

Answer False. Direct osseous repair (primary bone healing) is more consistent and more predictable than indirect repair, but is not necessarily regarded as faster. Ref: McGlamry’s Comprehensive Textbook of Foot and Ankle Surgery, Third Edition, Volume 1, Chapter 4, page 67.

 

4. Which of the following growth factors play a critical role of instigating and directing bone healing?

a. Platelet derived growth factor

b. Macrophage-derived growth factor

c. Transforming growth factor beta

d. All of the above

Answer D. Ref: McGlamry’s Comprehensive Textbook of Foot and Ankle Surgery, Third Edition, Volume 1, Chapter 4, page 66.

 

5. Which of the following Load / Fracture Pattern combinations is Incorrect?:

    LOAD

FRACTURE PATTERN
a. Torsional load spiral oblique fracture
b. Pure bending force  transverse fracture
c. Compression force  avulsion fracture
d. Combination force oblique fracture

Answer C. Each of the fracture patterns matches to its causative load except for the selected pair C. A compression force on a long bone will produce an impaction fracture within metaphyseal or epiphyseal regions. Ref: McGlamry’s Comprehensive Textbook of Foot and Ankle Surgery, Third Edition, Volume 1, Chapter 4, page 66.

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