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This PRESENT lecture is brought to you
by the generous sponsorship of
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Successful Wound Healing: Insights on Oasis
by Jeffrey Niezgoda, MD
Medical Director
Center for Comprehensive Wound Care and Hyperbaric Oxygen Therapy
St. Lukes Medical Center
Milwaukee, Wisconsin
The Oasis wound dressing is a
method of "jump starting" a wound through the proliferative phase of wound
healing. It is indicated for partial and full thickness wounds of various
etiologies. Oasis is derived from the submucosal layer of porcine small
intestine. Because it is acellular, it does not have any immunogenic properties.
Oasis contains predominantly Type I collagen as well as growth factors in a
latent form. The product is thin, porous, flexible, yet very strong. It is
packaged in a freeze dried state.
Dr. Jeffrey Niezgoda carefully describes the mechanism of action. He reviews the
phases of wound healing. The inflammatory phase (0-3 days), the proliferative
phase(3-21 days) and the remodeling phase.
In the proliferative phase, fibroblasts synthesize collagen. This provides the
strength required for wound healing. The collagen matrix provides a platform for
angiogenesis and neoepithelization.
Dr. Niezgoda describes how Oasis advances wound care in this proliferative
phase. Oasis serves as the scaffold which is eventually remodeled by the
patient's own cells.
It also contains growth factors including proteoglycans, glycoprotiens, and
glycosaminoglycans. The growth factors stimulate the proliferation of
granulation tissue. Proteoglycans bind with growth factors and allow them to
maintain their functionality. Glycoprotiens allow the host cells to bind to the
matrix and glycosaminoglycans enable the product to be incorporated into the
healed tissue.
Dr. Niezgoda demonstrates the application techniques and then presents some
impressive case studies that highlight the use of Oasis.
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